Yesterday I overheard "Easy-to-replace systems tend to get replaced with hard-to-replace systems." and now I can't stop thinking about whether this is just a restatement of the second law of thermodynamics in terms of systems design.
So go on, be weird. Out-weird the giants. Even if they're both nimble and powerful, they cannot be as stupid and ridiculous as you. Because how would that look? To managers, investors, board members, the general public? You can afford to completely disregard such entities.
“I once heard someone rail against how doctors totally ignored all the latest and most exciting medical studies. The same person, practically in the same breath, then railed against how 50% to 90% of medical studies are wrong.”
While I was away I missed this blockbuster paper, which suggests that many spatial persistence regressions may have inflated t-scores. At first glance, this looks like a much-needed paper. https://t.co/fvp7Nf5v3q
A three-color confetti illusion with spheres, which appear to be yellowish, reddish, and purpleish but in fact have exactly the same light-brown base color (RGB 255,188,144). Shrinking the image increases the effect. Original png file is at https://t.co/6r2PMbLMJc. https://t.co/ro1zpVxLm2
Well, we're going to have to get used to the idea that behaviors can leave genetic marks that make them transmissible to offspring. At least in nematodes, because we now have the detailed mechanisms: https://t.co/5TSwwZtcB9
@namalhotra @notstevenwhite @JohnHolbein1 @QJEHarvard This is the problem in #PublicHealth. We do outcome substitution so every intervention "works." When bad interventions/policies persist they undermine the chance for good ones to come to market. This finding is not unique to food desserts, many of our fave interventions prob fail
^ example of outcome substitution: planning to report change in all-cause mortality but then seeing that it is not statistically significant and instead reporting some significant change like decrease in cholesterol
@namalhotra @notstevenwhite @JohnHolbein1 @QJEHarvard At a top School of #PublicHealth I once saw a presentation where after consistently null findings were shown the speaker said "but in my heart I know it works," the audience nodded in agreement, and now years later the NIH is still funding this ineffective intervention.
The findings of this study are wild: "Almost every trial" pubbed in 5 high-impact med journals over a 6-week period had engaged in outcome switching. The authors sent correction letters to the journals & most were rejected https://t.co/u1NlncgsZC#bioethics#researchethics