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Better Than BDNF For The Brain? P-21 Peptide Explained.

Boost Your Biology Newsletter - By Ergogenic Health
Better Than BDNF For The Brain? P-21 Peptide Explained.
By Lucas Aoun • Issue #106 • View online
Hey everyone,
Today I want to chat about a new peptide on the market called P-21.
🏆 NEUROGENSIS ENHANCEMENT
P-21 is a nootropic peptide targeting improved neurogenesis. In animal studies, P21 has been shown to boost levels of BDNF, thus promoting neurogenesis (nerve growth) and inhibiting the formation of Amyloid plaques and Tau proteins seen in Alzheimer’s disease.
BDNF has been linked not just to enhanced neurogenesis, but to the down regulation of certain enzyme responsible for tau and amyloid plaque formation in Alzheimer’s brains.
P-21 has been shown to improve cognition in animal models.
P-21 has several effects in the central nervous system, but its primary impact is in the dentate gyrus where it acts to enhance neurogenesis and neuron maturation in the granular cell layer and sub-granular zone.
The dentate gyrus, which is part of the hippocampal formation in the temporal lobe of the brain, is thought to contribute to the formation of new episodic memories and the spontaneous exploration/learning that occurs in new environments.
Research in mouse models shows that P-21 does not bind to the CNTF receptor, suggesting that even though it is referred to as a mimetic, it should be clear that P-21 is not and analogue of CNTF. It appears, rather that P-21 acts to inhibit antibodies or other molecules that neutralize CNTF.
P-21 is a nootropic peptide of primary interest for its ability to promote neurogenesis both in health and disease.
In animal studies, administration of P-21 has been shown to boost levels of BDNF, thus promoting neurogenesis and inhibiting the formation of the plaques and defibrillation tangles seen in AD. The peptide may also have beneficial effects on satiety and weight gain. P-21 and cerebrolysin, though often confused, are not the same substance.

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Lucas Aoun (Founder of Ergogenic Health)
Lucas Aoun (Founder of Ergogenic Health)
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Lucas Aoun

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