You can unlock skills with gems (as usual), and between runs, select the skills you want to use. Unlike the prototype (which many of you played), you can only equip a few skills each time - so you need to think carefully and find synergies that work with your play-style.
I have 21 skills planned so far, including passive and active ones.
What skills are you excited about, interested in, or hope to see in the game? Hit reply and let me know!